1,892 research outputs found

    Wonders of Technology-Teaching Physics to Non-Scientists

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    Wonders of Technology is a conceptual physics course developed for non—science majors. The approach taken here in the introduction of the physical concepts is to depict their role in today’s technology, specifically the technology familiar to the students, and also to emphasize the connection between technology, art, and culture from the historical perspective. Why this approach? The traditional method of teaching physics is perceived by many students as user-unfriendly — they think physics is difficult, abstract, and, in fact, of little or no relevance to everyday life. The course Wonders of Technology alleviates this perception by placing the students on familiar ground that provides a fertile environment for an easier assimilation of knowledge. By examining the technology students use on a daily basis to demonstrate how physics makes things work, students are motivated to seek understanding of the principles underlying their operation. The course was developed within the guidelines of the new general education requirements at Virginia Commonwealth University. This presentation highlights some of the highly successful features of the newly developed course, with emphasis on responses from the education majors who are enrolled in the course

    Teaching Physical Science Through Technology: Middle School VCU PHY 591

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    Teaching Physical Science through Technology is a new 3-credit laboratory-and-lecture based course designed to serve as an introduction to the teaching of physical science concepts at the middle school level. Physical science phenomena are presented through investigations of commonly known applications of technology and focus on the Virginia Science Standards of Learning for 6th Grade Science and the Physical Science courses. Topics include matter, gravity, mechanics, heat, optics, electricity and magnetism, and computers as seen in their roles in common devices. The development of the course includes assessment from six semesters, collaboration with other institutions including the Science Museum of Virginia, and an 800 page text written by Adam Niculescu

    Attitudes in Physics Education: An Alternative Approach to Teaching Physics to Non-Science College Students

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    In this article, we present an alternative way of teaching conceptual physics for non-science majors by depicting the role of physics in today\u27s technology. The goal of this approach is to increase in the minds of non-science students the acceptance of physics as a useful component in general education, and as a major tool in comprehending the present-day technological world experienced by students outside the classroom

    Fly, Wake-up, Find: UAV-based Energy-efficient Localization for Distributed Sensor Nodes

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    A challenging application scenario in the field of industrial Unmanned Aerial Vehicles (UAVs) is the capability of a robot to find and query smart sensor nodes deployed at arbitrary locations in the mission area. This work explores the combination of different communication technologies, namely, Ultra-Wideband (UWB) and Wake-Up Radio (WUR), with a UAV that acts as a "ubiquitous local-host"of a Wireless Sensor Network (WSN). First, the UAV performs the localization of the sensor node via multiple UWB range measurements, and then it flies in its proximity to perform energy-efficient data acquisition. We propose an energy-efficient and accurate localization algorithm - based on multi-lateration - that is computationally inexpensive and robust to in-field noise. Aiming at minimizing the sensor node energy consumption, we also present a communication protocol that leverages WUR technology to minimize ON-time of the power-hungry UWB transceiver on the sensors. In-field experimental evaluation demonstrates that our approach achieves a sub-meter localization precision of the sensor nodes - i.e., down to 0.6 m - using only three range measurements, and runs in 4 ms on a low power microcontroller (ARM Cortex-M4F). Due to the presence of the WUR and the proposed lightweight algorithm, the entire localization-acquisition cycle requires only 31 mJ on the sensor node. The approach is suitable for several emerging Industrial Internet of Things application scenarios where a mobile vehicle needs to estimate the location of static objects without any precise knowledge of their position

    Optical and electrochemical studies of passive film formation in amorphous Ni‐Cr‐P‐C alloys

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    The investigation of passivation of an amorphous Ni‐l4Cr‐17P‐0.5C alloy in lN H2 SO4 through anodic polarization and near‐normal optical reflectance is reported. It was found that the alloy passivates with a current density of 10− 1 A/m2 extending to 1.0 V with current density dependent upon surface morphology. In the transpassive region under constant current density conditions the reflectance of the film exhibits strong interference phenomena and overall exponential decay in intensity. The behavior of the system in this region is described with a single thin‐film optical model consistent with the formation of a chromium phosphate deposit layer which increases in thickness at a rate of 7 nm/s at a 1.67 mV/s sweep rate

    Precision medicine for suicidality: from universality to subtypes and personalization

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    Suicide remains a clear, present and increasing public health problem, despite being a potentially preventable tragedy. Its incidence is particularly high in people with overt or un(der)diagnosed psychiatric disorders. Objective and precise identification of individuals at risk, ways of monitoring response to treatments and novel preventive therapeutics need to be discovered, employed and widely deployed. We sought to investigate whether blood gene expression biomarkers for suicide (that is, a ‘liquid biopsy’ approach) can be identified that are more universal in nature, working across psychiatric diagnoses and genders, using larger cohorts than in previous studies. Such markers may reflect and/or be a proxy for the core biology of suicide. We were successful in this endeavor, using a comprehensive stepwise approach, leading to a wealth of findings. Steps 1, 2 and 3 were discovery, prioritization and validation for tracking suicidality, resulting in a Top Dozen list of candidate biomarkers comprising the top biomarkers from each step, as well as a larger list of 148 candidate biomarkers that survived Bonferroni correction in the validation step. Step 4 was testing the Top Dozen list and Bonferroni biomarker list for predictive ability for suicidal ideation (SI) and for future hospitalizations for suicidality in independent cohorts, leading to the identification of completely novel predictive biomarkers (such as CLN5 and AK2), as well as reinforcement of ours and others previous findings in the field (such as SLC4A4 and SKA2). Additionally, we examined whether subtypes of suicidality can be identified based on mental state at the time of high SI and identified four potential subtypes: high anxiety, low mood, combined and non-affective (psychotic). Such subtypes may delineate groups of individuals that are more homogenous in terms of suicidality biology and behavior. We also studied a more personalized approach, by psychiatric diagnosis and gender, with a focus on bipolar males, the highest risk group. Such a personalized approach may be more sensitive to gender differences and to the impact of psychiatric co-morbidities and medications. We compared testing the universal biomarkers in everybody versus testing by subtypes versus personalized by gender and diagnosis, and show that the subtype and personalized approaches permit enhanced precision of predictions for different universal biomarkers. In particular, LHFP appears to be a strong predictor for suicidality in males with depression. We also directly examined whether biomarkers discovered using male bipolars only are better predictors in a male bipolar independent cohort than universal biomarkers and show evidence for a possible advantage of personalization. We identified completely novel biomarkers (such as SPTBN1 and C7orf73), and reinforced previously known biomarkers (such as PTEN and SAT1). For diagnostic ability testing purposes, we also examined as predictors phenotypic measures as apps (for suicide risk (CFI-S, Convergent Functional Information for Suicidality) and for anxiety and mood (SASS, Simplified Affective State Scale)) by themselves, as well as in combination with the top biomarkers (the combination being our a priori primary endpoint), to provide context and enhance precision of predictions. We obtained area under the curves of 90% for SI and 77% for future hospitalizations in independent cohorts. Step 5 was to look for mechanistic understanding, starting with examining evidence for the Top Dozen and Bonferroni biomarkers for involvement in other psychiatric and non-psychiatric disorders, as a mechanism for biological predisposition and vulnerability. The biomarkers we identified also provide a window towards understanding the biology of suicide, implicating biological pathways related to neurogenesis, programmed cell death and insulin signaling from the universal biomarkers, as well as mTOR signaling from the male bipolar biomarkers. In particular, HTR2A increase coupled with ARRB1 and GSK3B decreases in expression in suicidality may provide a synergistic mechanistical corrective target, as do SLC4A4 increase coupled with AHCYL1 and AHCYL2 decrease. Step 6 was to move beyond diagnostics and mechanistical risk assessment, towards providing a foundation for personalized therapeutics. Items scored positive in the CFI-S and subtypes identified by SASS in different individuals provide targets for personalized (psycho)therapy. Some individual biomarkers are targets of existing drugs used to treat mood disorders and suicidality (lithium, clozapine and omega-3 fatty acids), providing a means toward pharmacogenomics stratification of patients and monitoring of response to treatment. Such biomarkers merit evaluation in clinical trials. Bioinformatics drug repurposing analyses with the gene expression biosignatures of the Top Dozen and Bonferroni-validated universal biomarkers identified novel potential therapeutics for suicidality, such as ebselen (a lithium mimetic), piracetam (a nootropic), chlorogenic acid (a polyphenol) and metformin (an antidiabetic and possible longevity promoting drug). Finally, based on the totality of our data and of the evidence in the field to date, a convergent functional evidence score prioritizing biomarkers that have all around evidence (track suicidality, predict it, are reflective of biological predisposition and are potential drug targets) brought to the fore APOE and IL6 from among the universal biomarkers, suggesting an inflammatory/accelerated aging component that may be a targetable common denominator

    Locality of quark-hadron duality and deviations from quark counting rules above resonance region

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    We show how deviations from the dimensional scaling laws for exclusive processes may be related to a breakdown in the locality of quark-hadron duality. The essential principles are illustrated in a pedagogic model of a composite system with two spinless charged constituents, for which a dual picture for the low-energy resonance phenomena and high-energy scaling behavior can be established. We introduce the concept of "restricted locality" of quark-hadron duality and show how this results in deviations from the pQCD quark counting rules above the resonance region. In particular it can be a possible source for oscillations about the smooth quark counting rule, as seen e.g. in the 90-degree differential cross sections for Îłp→π+n\gamma p\to \pi^+ n.Comment: The way to present Eqs. (2), (4), (7) are changed while physics contents and calculations are left intact; Additional explanations for the forward and large-angle duality are added; Three more references are included; Version to appear on Phys. Rev. Let

    Towards a Sedimentology of Information Infrastructures: a Geological Approach for Understanding the City

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    Drawing primarily on ethnographic research performed in a city in Romania, this paper provides a thick description of police practices and information systems in that municipality. It shows various ways in which technologies mediate policing practitioners’ perceptions, decisions and actions. Bringing some additional material from a case in the Dutch police in which they build risk profiles predicated on real-time data from a sensor network, the paper highlights new phenomena with ethical implications emerging at the intersection of information infrastructures and policing practices. In particular, it shows a solidifying effect of technologically mediated suspicion, a sedimentation process in technological infrastructures and the formation of pockets of prejudice in the layers of software code. To adequately account for these phenomena and others, the paper provides a set of arguments and conditions for a sedimentology of infrastructures. At the same time, it offers the first steps in a larger research project that would adapt and test the limits of a geological vocabulary and approach to understand smart urban environments.Cybersecurity en cybergovernanc
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